Oxandrolone (commonly known as Anavar) was introduced in the 1960s by the company "Searle" with the goal of creating an **extremely mild anabolic steroid** that would be safe for growing children. It was the first and only steroid proven not to negatively impact the closure of growth plates in bones. It was successfully used as a growth stimulant for children and adolescents with stunted growth.

Current Clinical Use:

• Treatment of **osteoporosis** in women.
• Combating rapid loss of muscle mass and strength in **AIDS patients**.

Oxandrolone is characterized by a mild anabolic effect and very low androgenicity. Users should not expect spectacular mass gains. However, it is exceptional in terms of other properties:

• No Aromatization: The substance does not convert to estrogen, which eliminates water and fat retention, contributing to **improved muscle hardness and quality**.
• Strength Increase: It stimulates the synthesis of **creatine phosphate**, resulting in significant strength gains. This is crucial for maintaining strength (and muscle mass) during a rigorous diet.
• High-Quality Gain: Novices may observe a small but **high-quality and durable muscle gain**.

Due to its mild effect and high cost, Oxandrolone is **not cost-effective for typical bulking phases**. Its use makes the most sense during **dieting, fat reduction, and contest preparation phases**.

Oxandrolone is well tolerated. Its half-life is approximately **9.4 hours**, so the total daily dose should be divided into **two or three portions**, taken with meals to minimize potential gastrointestinal issues.

Dosing:

• **Beginners / Women:** 10–25 mg daily (Women achieve good results with minimal risk of virilization).
• **Advanced Users (Cutting):** 20–40 mg daily.
• **Maximum Duration of Use:** 6–8 weeks.

Stacks:

Oxandrolone is often used in stacks aimed at maximizing muscle quality and hardness, especially during cutting:

• Strength / Hard Musculature: Oxandrolone + **Stanozolol** (e.g., 30 mg Oxa + 50 mg Stanozolol every 2 days).
• Cutting / Contest Prep: Oxandrolone + **Testosterone Propionate**, **Trenbolone**, and **Stanozolol**.
• Women (Mass): Oxandrolone + **Nandrolone Decanoate** or **Methenolone Enanthate**.

Oxandrolone is 17-alpha alkylated, which places some **stress on the liver**. However, this risk is extremely minimal at doses around 20 mg daily and usage not exceeding 6–8 weeks. It should be avoided in combination with other 17-alpha alkylated steroids (Methandienone, Oxymetholone, Halotestin).

Side Effects:

Generally mild and well-tolerated. Sensitive athletes may report acne, body hair growth, and scalp hair loss (mild androgenicity).

PCT:

At moderate doses (10–30 mg daily), Oxandrolone **minimally affects natural testosterone production**. When using Oxandrolone alone for 4–8 weeks, Post Cycle Therapy (PCT) **may be unnecessary**.